InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ANAPC2

Summary

InnateDB Gene

IDBG-93182.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANAPC2

Gene Name

anaphase promoting complex subunit 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000176248

Encoded Proteins

IDBP-93184

anaphase promoting complex subunit 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:137174784-137188549

Strand

Reverse strand

Band

q34.3

Transcripts

ENST00000323927	ENSP00000314004
ENST00000487917
ENST00000493730
ENST00000483432
ENST00000485970
ENST00000471131
ENST00000495611
ENST00000618649

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	84 [view]
Protein-Protein	84 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000278	mitotic cell cycle
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007067	mitotic nuclear division
GO:0007094	mitotic spindle assembly checkpoint
GO:0008054	cyclin catabolic process
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031915	positive regulation of synaptic plasticity
GO:0045773	positive regulation of axon extension
GO:0050775	positive regulation of dendrite morphogenesis
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070979	protein K11-linked ubiquitination
GO:0090129	positive regulation of synapse maturation