Version 5.4
Homo sapiens Gene: SNX14
Summary
InnateDB Gene IDBG-93996.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNX14
Gene Name sorting nexin 14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135317
Encoded Proteins
IDBP-93998
sorting nexin 14
IDBP-94000
sorting nexin 14
IDBP-94002
sorting nexin 14
IDBP-94006
sorting nexin 14
IDBP-385050
sorting nexin 14
IDBP-480625
sorting nexin 14
IDBP-479590
sorting nexin 14
IDBP-479839
sorting nexin 14
IDBP-475424
sorting nexin 14
IDBP-483924
sorting nexin 14
IDBP-482652
sorting nexin 14
IDBP-478422
sorting nexin 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:85505496-85594156
Strand Reverse strand
Band q14.3
Transcripts
ENST00000369635 ENSP00000358649
ENST00000314673 ENSP00000313121
ENST00000346348 ENSP00000257769
ENST00000369627 ENSP00000358641
ENST00000418862 ENSP00000391981
ENST00000513865 ENSP00000420938
ENST00000474645
ENST00000505648 ENSP00000427380
ENST00000508980
ENST00000503491
ENST00000508658 ENSP00000422814
ENST00000515216 ENSP00000425630
ENST00000503608
ENST00000506182
ENST00000514801
ENST00000504191
ENST00000509338 ENSP00000424302
ENST00000514419 ENSP00000425387
ENST00000513869 ENSP00000426806
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0015031 protein transport
GO:0038032 termination of G-protein coupled receptor signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032422
View Gene Order
ENSBTAG00000018408
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.485871 Hs.665610
RefSeq NM_001297614 NM_020468 NM_153816 XM_005248738 XM_005248739
HUGO
OMIM
CCDS CCDS5003 CCDS5004 CCDS75490
HPRD 11590
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca