Version 5.4
Homo sapiens Gene: RHD
Summary
InnateDB Gene IDBG-94290.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHD
Gene Name Rh blood group, D antigen
Synonyms CD240D; DIIIc; RH; RH30; Rh4; RHCED; RhDCw; RHDel; RHDVA(TT); RhII; RhK562-II; RhPI; RHPII; RHXIII
Species Homo sapiens
Ensembl Gene ENSG00000187010
Encoded Proteins
IDBP-94292
Rh blood group, D antigen
IDBP-94294
Rh blood group, D antigen
IDBP-94296
Rh blood group, D antigen
IDBP-375790
Rh blood group, D antigen
IDBP-375794
Rh blood group, D antigen
IDBP-375799
Rh blood group, D antigen
IDBP-721558
IDBP-813311
Rh blood group, D antigen
IDBP-813328
Rh blood group, D antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:25272393-25330445
Strand Forward strand
Band p36.11
Transcripts
ENST00000328664 ENSP00000331871
ENST00000357542 ENSP00000350150
ENST00000342055 ENSP00000339577
ENST00000454452 ENSP00000413849
ENST00000417538 ENSP00000396420
ENST00000423810 ENSP00000399640
ENST00000423253
ENST00000568195 ENSP00000456966
ENST00000564398
ENST00000622561 ENSP00000478087
ENST00000615607 ENSP00000480925
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008519 ammonium transmembrane transporter activity
Biological Process
GO:0015696 ammonium transport
GO:0072488 ammonium transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.449968
RefSeq NM_001127691 NM_001282867 NM_001282868 NM_001282869 NM_001282870 NM_001282871 NM_001282872 NM_016124 XM_006710810
HUGO
OMIM
CCDS CCDS262 CCDS53285 CCDS60027 CCDS60028 CCDS60029 CCDS60030 CCDS60031
HPRD 00199
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca