Version 5.4
Homo sapiens Gene: UBXN11
Summary
InnateDB Gene IDBG-94543.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBXN11
Gene Name UBX domain protein 11
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000158062
Encoded Proteins
IDBP-94551
UBX domain protein 11
IDBP-94553
UBX domain protein 11
IDBP-94555
UBX domain protein 11
IDBP-94559
UBX domain protein 11
IDBP-94563
UBX domain protein 11
IDBP-94565
UBX domain protein 11
IDBP-94569
UBX domain protein 11
IDBP-376365
UBX domain protein 11
IDBP-376367
UBX domain protein 11
IDBP-376368
UBX domain protein 11
IDBP-376369
UBX domain protein 11
IDBP-376371
UBX domain protein 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:26281328-26318363
Strand Reverse strand
Band p36.11
Transcripts
ENST00000374223 ENSP00000363340
ENST00000374222 ENSP00000363339
ENST00000374221 ENSP00000363338
ENST00000357089 ENSP00000349601
ENST00000314675 ENSP00000324721
ENST00000374217 ENSP00000363334
ENST00000374215 ENSP00000363332
ENST00000452980 ENSP00000410357
ENST00000442942 ENSP00000404956
ENST00000450041 ENSP00000413448
ENST00000423664 ENSP00000394036
ENST00000421827 ENSP00000395165
ENST00000472155
ENST00000475591
ENST00000494942
ENST00000496466
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000012126
View Gene Order
ENSBTAG00000009581
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.145061 Hs.616515
RefSeq NM_001077262 NM_145345 NM_183008
HUGO
OMIM
CCDS CCDS41286 CCDS41287 CCDS41288
HPRD 10245
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca