InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRIK2

Summary

InnateDB Gene

IDBG-94705.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIK2

Gene Name

glutamate receptor, ionotropic, kainate 2

Synonyms

EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6

Species

Homo sapiens

Ensembl Gene

ENSG00000164418

Encoded Proteins

IDBP-94707

glutamate receptor, ionotropic, kainate 2

IDBP-94711

glutamate receptor, ionotropic, kainate 2

IDBP-94713

glutamate receptor, ionotropic, kainate 2

IDBP-94715

glutamate receptor, ionotropic, kainate 2

IDBP-94717

glutamate receptor, ionotropic, kainate 2

IDBP-385632

glutamate receptor, ionotropic, kainate 2

IDBP-385637

glutamate receptor, ionotropic, kainate 2

IDBP-385640

glutamate receptor, ionotropic, kainate 2

IDBP-385641

glutamate receptor, ionotropic, kainate 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:101398788-102070083

Strand

Forward strand

Band

q16.3

Transcripts

ENST00000369138	ENSP00000358134
ENST00000369137	ENSP00000358133
ENST00000318991	ENSP00000313276
ENST00000358361	ENSP00000351128
ENST00000369134	ENSP00000358130
ENST00000413795	ENSP00000405596
ENST00000421544	ENSP00000397026
ENST00000455610	ENSP00000391988
ENST00000436862	ENSP00000407140
ENST00000487395
ENST00000487161

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity
GO:0015277	kainate selective glutamate receptor activity
GO:0030165	PDZ domain binding
GO:0031624	ubiquitin conjugating enzyme binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001662	behavioral fear response
GO:0006810	transport
GO:0006874	cellular calcium ion homeostasis
GO:0006886	intracellular protein transport
GO:0007165	signal transduction
GO:0007215	glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0019228	neuronal action potential
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042391	regulation of membrane potential
GO:0043113	receptor clustering
GO:0043524	negative regulation of neuron apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0046328	regulation of JNK cascade
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0050804	regulation of synaptic transmission
GO:0050806	positive regulation of synaptic transmission
GO:0051402	neuron apoptotic process
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060080	regulation of inhibitory postsynaptic membrane potential

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008328	ionotropic glutamate receptor complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0032839	dendrite cytoplasm
GO:0032983	kainate selective glutamate receptor complex
GO:0042734	presynaptic membrane
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043204	perikaryon
GO:0045202	synapse
GO:0045211	postsynaptic membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000056073

View Gene Order

ENSBTAG00000033153

Not yet available

Pathways

NETPATH

REACTOME

REACT_21343

Activation of Na-permeable Kainate Receptors pathway

REACT_13685

Neuronal System pathway

REACT_21322

Ionotropic activity of Kainate Receptors pathway

REACT_21312

Activation of Kainate Receptors upon glutamate binding pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_21346

Activation of Ca-permeable Kainate Receptor pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.605579 Hs.98262

RefSeq

NM_001166247 NM_021956 NM_175768 XM_005266945 XM_005266946 XM_006715465

HUGO

OMIM

CCDS

CCDS5048 CCDS5049 CCDS55045

HPRD

00692

IMGT

EMBL

GenPept

RNA Seq Atlas