Version 5.4
Homo sapiens Gene: KPNA6
Summary
InnateDB Gene IDBG-95575.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KPNA6
Gene Name karyopherin alpha 6 (importin alpha 7)
Synonyms IPOA7; KPNA7
Species Homo sapiens
Ensembl Gene ENSG00000025800
Encoded Proteins
IDBP-95577
karyopherin alpha 6 (importin alpha 7)
IDBP-378674
karyopherin alpha 6 (importin alpha 7)
IDBP-809805
karyopherin alpha 6 (importin alpha 7)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:32108038-32176568
Strand Forward strand
Band p35.2
Transcripts
ENST00000373625 ENSP00000362728
ENST00000446515 ENSP00000415677
ENST00000471599 ENSP00000474234
ENST00000469790
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008565 protein transporter activity
Biological Process
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060135 maternal process involved in female pregnancy
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003731
View Gene Order
ENSBTAG00000002896
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL S4R3E5
UniProt Splice Variant
Entrez Gene 23633
UniGene
RefSeq NM_012316 XM_005270711
HUGO HGNC:6399
OMIM 610563
CCDS CCDS352
HPRD
IMGT
EMBL AL049795 AL445248
GenPept
RNA Seq Atlas 23633

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca