Version 5.4
Homo sapiens Gene: LCK
Summary
InnateDB Gene IDBG-95667.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LCK
Gene Name lymphocyte-specific protein tyrosine kinase
Synonyms IMD22; LSK; p56lck; pp58lck; YT16
Species Homo sapiens
Ensembl Gene ENSG00000182866
Encoded Proteins
IDBP-95671
lymphocyte-specific protein tyrosine kinase
IDBP-95673
lymphocyte-specific protein tyrosine kinase
IDBP-95675
lymphocyte-specific protein tyrosine kinase
IDBP-95677
lymphocyte-specific protein tyrosine kinase
IDBP-95679
lymphocyte-specific protein tyrosine kinase
IDBP-591652
lymphocyte-specific protein tyrosine kinase
IDBP-598488
lymphocyte-specific protein tyrosine kinase
IDBP-591014
lymphocyte-specific protein tyrosine kinase
IDBP-590949
lymphocyte-specific protein tyrosine kinase
IDBP-807796
LCK proto-oncogene, Src family tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:32251239-32286165
Strand Forward strand
Band p35.2
Transcripts
ENST00000355928
ENST00000373564 ENSP00000362665
ENST00000336890 ENSP00000337825
ENST00000333070 ENSP00000328213
ENST00000373562 ENSP00000362663
ENST00000373557 ENSP00000362658
ENST00000482949 ENSP00000431517
ENST00000461712 ENSP00000434525
ENST00000495610 ENSP00000435605
ENST00000476457
ENST00000469765
ENST00000477031 ENSP00000436554
ENST00000469956
ENST00000619559 ENSP00000477713
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 168 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 168 [view]
Protein-Protein 168 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0003823 antigen binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0032403 protein complex binding
GO:0042169 SH2 domain binding
GO:0042609 CD4 receptor binding
GO:0042610 CD8 receptor binding
GO:0042802 identical protein binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0051117 ATPase binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006882 cellular zinc ion homeostasis
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166 cell surface receptor signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007568 aging
GO:0007596 blood coagulation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009612 response to mechanical stimulus
GO:0010038 response to metal ion
GO:0010043 response to zinc ion
GO:0010628 positive regulation of gene expression
GO:0016032 viral process
GO:0016311 dephosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030097 hemopoiesis
GO:0030168 platelet activation
GO:0030217 T cell differentiation
GO:0031295 T cell costimulation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042493 response to drug
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042542 response to hydrogen peroxide
GO:0045087 innate immune response
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050690 regulation of defense response to virus by virus
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0050856 regulation of T cell receptor signaling pathway
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0050900 leukocyte migration
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051249 regulation of lymphocyte activation
GO:0070474 positive regulation of uterine smooth muscle contraction
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0000242 pericentriolar material
GO:0001772 immunological synapse
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0030139 endocytic vesicle
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000409
View Gene Order
ENSBTAG00000012695
Not yet available
Pathways
NETPATH
NetPath_3
Notch pathway
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_22
Leptin pathway
NetPath_24
TSLP pathway
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12555
Downstream TCR signaling pathway
REACT_12623
Generation of second messenger molecules pathway
REACT_12596
Translocation of ZAP-70 to Immunological synapse pathway
REACT_12582
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_19405
CTLA4 inhibitory signaling pathway
REACT_19358
CD28 dependent PI3K/Akt signaling pathway
REACT_19238
CD28 dependent Vav1 pathway pathway
REACT_19183
CD28 co-stimulation pathway
REACT_19324
PD-1 signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_12519
PECAM1 interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111225
Regulation of KIT signaling pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_11068
Nef and signal transduction pathway
REACT_11166
Nef Mediated CD4 Down-regulation pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_12526
TCR signaling pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_6185
HIV Infection pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05340
Primary immunodeficiency pathway
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
Integrin signaling pathway pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
nfkappabatypicalpathway
Atypical NF-kappaB pathway
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
il2_1pathway
IL2-mediated signaling events
cxcr4_pathway
CXCR4-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
il12_2pathway
IL12-mediated signaling events
shp2_pathway
SHP2 signaling
il2_stat5pathway
IL2 signaling events mediated by STAT5
il2_pi3kpathway
IL2 signaling events mediated by PI3K
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.470627
RefSeq NM_001042771 NM_005356 XM_005270864
HUGO
OMIM
CCDS CCDS359
HPRD 01080
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca