Version 5.4
Homo sapiens Gene: KPNA5
Summary
InnateDB Gene IDBG-95727.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KPNA5
Gene Name karyopherin alpha 5 (importin alpha 6)
Synonyms IPOA6; SRP6
Species Homo sapiens
Ensembl Gene ENSG00000196911
Encoded Proteins
IDBP-95729
karyopherin alpha 5 (importin alpha 6)
IDBP-95731
karyopherin alpha 5 (importin alpha 6)
IDBP-245499
karyopherin alpha 5 (importin alpha 6)
IDBP-386363
karyopherin alpha 5 (importin alpha 6)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:116681187-116741866
Strand Forward strand
Band q22.1
Transcripts
ENST00000368564 ENSP00000357552
ENST00000356348 ENSP00000348704
ENST00000392517 ENSP00000376302
ENST00000413340 ENSP00000396791
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008565 protein transporter activity
Biological Process
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_115831
ISG15 antiviral mechanism pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O15131
TrEMBL Q5TD90
UniProt Splice Variant
Entrez Gene 3841
UniGene Hs.182971 Hs.601225 Hs.658084 Hs.741438
RefSeq XM_006715474 NM_002269 XM_005266964
HUGO HGNC:6398
OMIM 604545
CCDS CCDS5111
HPRD 05179
IMGT
EMBL AF005361 AK314206 AL132795 AL354716 BC047409 CH471051
GenPept AAC51868 AAH47409 BAG36882 CAI20500 EAW48216
RNA Seq Atlas 3841

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca