InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HEY2

Summary

InnateDB Gene

IDBG-96125.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HEY2

Gene Name

hairy/enhancer-of-split related with YRPW motif 2

Synonyms

bHLHb32; CHF1; GRIDLOCK; GRL; HERP1; HESR2; HRT2

Species

Homo sapiens

Ensembl Gene

ENSG00000135547

Encoded Proteins

IDBP-96127

hairy/enhancer-of-split related with YRPW motif 2

IDBP-96129

hairy/enhancer-of-split related with YRPW motif 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:125747664-125761269

Strand

Forward strand

Band

q22.31

Transcripts

ENST00000368365	ENSP00000357349
ENST00000368364	ENSP00000357348

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000983	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0000988	protein binding transcription factor activity
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0035939	microsatellite binding
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001568	blood vessel development
GO:0001570	vasculogenesis
GO:0003150	muscular septum morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0003171	atrioventricular valve development
GO:0003184	pulmonary valve morphogenesis
GO:0003186	tricuspid valve morphogenesis
GO:0003195	tricuspid valve formation
GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0003208	cardiac ventricle morphogenesis
GO:0003214	cardiac left ventricle morphogenesis
GO:0003215	cardiac right ventricle morphogenesis
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0003300	cardiac muscle hypertrophy
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007219	Notch signaling pathway
GO:0007389	pattern specification process
GO:0007507	heart development
GO:0009948	anterior/posterior axis specification
GO:0010460	positive regulation of heart rate
GO:0010468	regulation of gene expression
GO:0010621	negative regulation of transcription by transcription factor localization
GO:0010629	negative regulation of gene expression
GO:0010667	negative regulation of cardiac muscle cell apoptotic process
GO:0014031	mesenchymal cell development
GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0035910	ascending aorta morphogenesis
GO:0035912	dorsal aorta morphogenesis
GO:0036304	umbilical cord morphogenesis
GO:0045165	cell fate commitment
GO:0045607	regulation of auditory receptor cell differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051145	smooth muscle cell differentiation
GO:0055015	ventricular cardiac muscle cell development
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060347	heart trabecula formation
GO:0060411	cardiac septum morphogenesis
GO:0060412	ventricular septum morphogenesis
GO:0060413	atrial septum morphogenesis
GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter
GO:0060716	labyrinthine layer blood vessel development
GO:0060840	artery development
GO:0060842	arterial endothelial cell differentiation
GO:0060948	cardiac vascular smooth muscle cell development
GO:0060977	coronary vasculature morphogenesis
GO:0061156	pulmonary artery morphogenesis
GO:0061314	Notch signaling involved in heart development
GO:0065004	protein-DNA complex assembly
GO:0090102	cochlea development
GO:0097084	vascular smooth muscle cell development
GO:2000678	negative regulation of transcription regulatory region DNA binding
GO:2000723	negative regulation of cardiac vascular smooth muscle cell differentiation
GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
GO:2001212	regulation of vasculogenesis