Version 5.4
Homo sapiens Gene: OR2A4
Summary
InnateDB Gene IDBG-96581.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OR2A4
Gene Name olfactory receptor, family 2, subfamily A, member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000180658
Encoded Proteins
IDBP-96583
olfactory receptor, family 2, subfamily A, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:131700469-131701401
Strand Reverse strand
Band q23.2
Transcripts
ENST00000315453 ENSP00000319546
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004930 G-protein coupled receptor activity
GO:0004984 olfactory receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032467 positive regulation of cytokinesis
GO:0032956 regulation of actin cytoskeleton organization
GO:0050911 detection of chemical stimulus involved in sensory perception of smell
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0032154 cleavage furrow
GO:0055037 recycling endosome
GO:0090543 Flemming body
GO:0097431 mitotic spindle pole
GO:1990023 mitotic spindle midzone
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_15488
Olfactory Signaling Pathway pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
hsa04740
Olfactory transduction pathway
INOH
PID NCI
Cross-References
SwissProt O95047
TrEMBL
UniProt Splice Variant
Entrez Gene 79541
UniGene Hs.734368
RefSeq NM_030908
HUGO HGNC:14729
OMIM
CCDS CCDS5149
HPRD
IMGT
EMBL AC005587 AL135904 BC120953 BC120954 BK004444
GenPept AAD05193 AAI20954 AAI20955 CAB99212 DAA04842
RNA Seq Atlas 79541

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca