InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HEYL

Summary

InnateDB Gene

IDBG-96732.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HEYL

Gene Name

hairy/enhancer-of-split related with YRPW motif-like

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000163909

Encoded Proteins

IDBP-96734

hairy/enhancer-of-split related with YRPW motif-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:39624153-39639945

Strand

Reverse strand

Band

p34.2

Transcripts

ENST00000372852

ENSP00000361943

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000983	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0000988	protein binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0035939	microsatellite binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0050683	AF-1 domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0003151	outflow tract morphogenesis
GO:0003181	atrioventricular valve morphogenesis
GO:0003184	pulmonary valve morphogenesis
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203	endocardial cushion morphogenesis
GO:0003208	cardiac ventricle morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007219	Notch signaling pathway
GO:0010629	negative regulation of gene expression
GO:0014031	mesenchymal cell development
GO:0032835	glomerulus development
GO:0035914	skeletal muscle cell differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060412	ventricular septum morphogenesis
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0071773	cellular response to BMP stimulus
GO:0072014	proximal tubule development
GO:2000824	negative regulation of androgen receptor activity