Version 5.4
Homo sapiens Gene: KATNA1
Summary
InnateDB Gene IDBG-97750.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KATNA1
Gene Name katanin p60 (ATPase containing) subunit A 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186625
Encoded Proteins
IDBP-97752
katanin p60 (ATPase containing) subunit A 1
IDBP-97754
katanin p60 (ATPase containing) subunit A 1
IDBP-97756
katanin p60 (ATPase containing) subunit A 1
IDBP-387742
katanin p60 (ATPase containing) subunit A 1
IDBP-387743
katanin p60 (ATPase containing) subunit A 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:149594873-149648972
Strand Reverse strand
Band q25.1
Transcripts
ENST00000335643 ENSP00000335180
ENST00000335647 ENSP00000335106
ENST00000367411 ENSP00000356381
ENST00000444282 ENSP00000390322
ENST00000420200 ENSP00000398993
ENST00000494504
ENST00000481905
ENST00000470620
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0008568 microtubule-severing ATPase activity
GO:0009378 four-way junction helicase activity
GO:0016887 ATPase activity
GO:0045502 dynein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001578 microtubule bundle formation
GO:0001764 neuron migration
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0007067 mitotic nuclear division
GO:0008104 protein localization
GO:0010977 negative regulation of neuron projection development
GO:0031122 cytoplasmic microtubule organization
GO:0051013 microtubule severing
GO:0051329 interphase of mitotic cell cycle
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005811 lipid particle
GO:0005813 centrosome
GO:0005819 spindle
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0030424 axon
GO:0030426 growth cone
GO:0030496 midbody
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019794
View Gene Order
ENSBTAG00000032024
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.450175
RefSeq NM_001204076 NM_007044 XM_005266804
HUGO
OMIM
CCDS CCDS5217 CCDS56456
HPRD 05986
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca