Version 5.4
Homo sapiens Gene: RPS6KA2
Summary
InnateDB Gene IDBG-98954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPS6KA2
Gene Name ribosomal protein S6 kinase, 90kDa, polypeptide 2
Synonyms HU-2; MAPKAPK1C; p90-RSK3; pp90RSK3; RSK; RSK3; S6K-alpha; S6K-alpha2
Species Homo sapiens
Ensembl Gene ENSG00000071242
Encoded Proteins
IDBP-98956
ribosomal protein S6 kinase, 90kDa, polypeptide 2
IDBP-293048
ribosomal protein S6 kinase, 90kDa, polypeptide 2
IDBP-485302
ribosomal protein S6 kinase, 90kDa, polypeptide 2
IDBP-481069
ribosomal protein S6 kinase, 90kDa, polypeptide 2
IDBP-481772
ribosomal protein S6 kinase, 90kDa, polypeptide 2
IDBP-483460
ribosomal protein S6 kinase, 90kDa, polypeptide 2
IDBP-480984
ribosomal protein S6 kinase, 90kDa, polypeptide 2
IDBP-479615
ribosomal protein S6 kinase, 90kDa, polypeptide 2
IDBP-480033
ribosomal protein S6 kinase, 90kDa, polypeptide 2
IDBP-478118
ribosomal protein S6 kinase, 90kDa, polypeptide 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:166409364-166906451
Strand Reverse strand
Band q27
Transcripts
ENST00000265678 ENSP00000265678
ENST00000366865
ENST00000405189 ENSP00000386050
ENST00000510118 ENSP00000422435
ENST00000503859 ENSP00000427015
ENST00000509742
ENST00000481261 ENSP00000422484
ENST00000491836
ENST00000507350 ENSP00000422197
ENST00000512860 ENSP00000427605
ENST00000507371 ENSP00000423114
ENST00000506565 ENSP00000425148
ENST00000511034 ENSP00000425458
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 22 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004711 ribosomal protein S6 kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0001556 oocyte maturation
GO:0002035 brain renin-angiotensin system
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0007507 heart development
GO:0008285 negative regulation of cell proliferation
GO:0009103 lipopolysaccharide biosynthetic process
GO:0010628 positive regulation of gene expression
GO:0010659 cardiac muscle cell apoptotic process
GO:0018105 peptidyl-serine phosphorylation
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035556 intracellular signal transduction
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response
GO:0045786 negative regulation of cell cycle
GO:0045835 negative regulation of meiosis
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051403 stress-activated MAPK cascade
GO:0060047 heart contraction
GO:0070613 regulation of protein processing
GO:0071322 cellular response to carbohydrate stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023809
View Gene Order
ENSBTAG00000021741
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_18
IL6 pathway
NetPath_22
Leptin pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_12599
ERK/MAPK targets pathway
REACT_12524
CREB phosphorylation pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_20510
RSK activation pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_120956
Cellular responses to stress pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_13685
Neuronal System pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_6900
Immune System pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_169274
Cellular Senescence pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_12433
Nuclear Events (kinase and transcription factor activation) pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa04720
Long-term potentiation pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04114
Oocyte meiosis pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL D6RD75
UniProt Splice Variant
Entrez Gene 6196
UniGene Hs.655277
RefSeq NM_001006932 NM_021135 XM_005267092 XM_006715549
HUGO HGNC:10431
OMIM 601685
CCDS CCDS34570 CCDS5294
HPRD 03403
IMGT
EMBL AL022069 AL023775 AL159163 Z98049
GenPept
RNA Seq Atlas 6196

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca