InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ROR1

Summary

InnateDB Gene

IDBG-99419.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ROR1

Gene Name

receptor tyrosine kinase-like orphan receptor 1

Synonyms

dJ537F10.1; NTRKR1

Species

Homo sapiens

Ensembl Gene

ENSG00000185483

Encoded Proteins

IDBP-99421

receptor tyrosine kinase-like orphan receptor 1

IDBP-99423

receptor tyrosine kinase-like orphan receptor 1

IDBP-603973

receptor tyrosine kinase-like orphan receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:63774022-64181498

Strand

Forward strand

Band

p31.3

Transcripts

ENST00000371080	ENSP00000360121
ENST00000371079	ENSP00000360120
ENST00000482426
ENST00000545203	ENSP00000441637

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017147	Wnt-protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0018108	peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0043235	receptor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000035305

View Gene Order

ENSBTAG00000012312

Not yet available

Pathways

NETPATH

NetPath_8

Wnt pathway

REACTOME

REACT_172581

PCP/CE pathway pathway

REACT_172694

beta-catenin independent WNT signaling pathway

REACT_11045

Signaling by Wnt pathway

REACT_111102

Signal Transduction pathway

REACT_172631

WNT5A-dependent internalization of FZD2, FZD5 and ROR2 pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.128753

RefSeq

NM_001083592 NM_005012

HUGO

OMIM

CCDS

CCDS41344 CCDS626

HPRD

03821

IMGT

EMBL

GenPept

RNA Seq Atlas