InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LPAR3

Summary

InnateDB Protein

IDBP-100002.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPAR3

Protein Name

lysophosphatidic acid receptor 3

Synonyms

Edg-7; EDG7; GPCR; HOFNH30; LP-A3; LPA3; RP4-678I3;

Species

Homo sapiens

Ensembl Protein

ENSP00000359643

InnateDB Gene

IDBG-100000 (LPAR3)

Protein Structure

UniProt Annotation

Function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008289	lipid binding
GO:0070915	lysophosphatidic acid receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007268	synaptic transmission

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001671 Melanocortin/ACTH receptor
IPR002277 Lysophosphatidic acid receptor EDG-2
IPR004065 Lysophosphatidic acid receptor
IPR005385 Lysophosphatidic acid receptor EDG-7
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00534
PR01148
PR01527
PR01560

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UBY5