InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCL10

Summary

InnateDB Protein

IDBP-100048.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL10

Protein Name

B-cell CLL/lymphoma 10

Synonyms

c-E10; CARMEN; CIPER; CLAP; mE10;

Species

Homo sapiens

Ensembl Protein

ENSP00000359612

InnateDB Gene

IDBG-100044 (BCL10)

Protein Structure

UniProt Annotation

Function

Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1. {ECO:0000269PubMed:18264101}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:17287217}. Membrane raft {ECO:0000269PubMed:17287217}. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.

Disease Associations

Note=A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.Note=Defects in BCL10 are involved in various types of cancer.Mesothelioma, malignant (MESOM) [MIM:156240]: An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle- shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. Note=The gene represented in this entry may be involved in disease pathogenesis.

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	100 [view]
Protein-Protein	99 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0019209	kinase activator activity
GO:0019899	enzyme binding
GO:0019900	kinase binding
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0043130	ubiquitin binding
GO:0043422	protein kinase B binding
GO:0043621	protein self-association
GO:0051059	NF-kappaB binding

Biological Process

GO:0001783	B cell apoptotic process
GO:0001843	neural tube closure
GO:0002224	toll-like receptor signaling pathway
GO:0002237	response to molecule of bacterial origin
GO:0002250	adaptive immune response
GO:0002906	negative regulation of mature B cell apoptotic process
GO:0006968	cellular defense response
GO:0008219	cell death
GO:0009620	response to fungus
GO:0016064	immunoglobulin mediated immune response
GO:0031398	positive regulation of protein ubiquitination
GO:0032094	response to food
GO:0032765	positive regulation of mast cell cytokine production
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042109	lymphotoxin A biosynthetic process
GO:0042226	interleukin-6 biosynthetic process
GO:0042327	positive regulation of phosphorylation
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050852	T cell receptor signaling pathway
GO:0050856	regulation of T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051259	protein oligomerization
GO:0051260	protein homooligomerization
GO:0070231	T cell apoptotic process
GO:0071260	cellular response to mechanical stimulus
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005829	cytosol
GO:0005881	cytoplasmic microtubule
GO:0005886	plasma membrane
GO:0032449	CBM complex
GO:0042101	T cell receptor complex
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0046696	lipopolysaccharide receptor complex
GO:0048471	perinuclear region of cytoplasm