InnateDB Protein
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IDBP-100139.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PKN2
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Protein Name
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protein kinase N2
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Synonyms
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Pak-2; PAK2; PRK2; PRKCL2; PRO2042; STK7;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359536
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InnateDB Gene
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IDBG-100129 (PKN2)
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Protein Structure
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Function |
PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c- fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269PubMed:10226025, ECO:0000269PubMed:10926925, ECO:0000269PubMed:11777936, ECO:0000269PubMed:11781095, ECO:0000269PubMed:15364941, ECO:0000269PubMed:17332740, ECO:0000269PubMed:20188095, ECO:0000269PubMed:20974804, ECO:0000269PubMed:21754995, ECO:0000269PubMed:9121475}.
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Subcellular Localization |
Cytoplasm. Nucleus. Membrane {ECO:0000250}. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Cleavage furrow. Midbody. Cell junction. Note=Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells. In the course of viral infection, colocalizes with HCV NS5B at perinuclear region in the cytoplasm.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Expressed in numerous tumor cell lines, especially in bladder tumor cells. {ECO:0000269PubMed:10026169, ECO:0000269PubMed:21754995}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
49
[view]
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Protein-Protein |
44
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000008
C2 domain
IPR011072
HR1 rho-binding repeat
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PFAM |
PF00168
PF02185
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PRINTS |
PR00360
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PIRSF |
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SMART |
SM00239
SM00742
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TIGRFAMs |
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Modification |
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SwissProt |
Q16513
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PhosphoSite |
PhosphoSite-Q16513
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TrEMBL |
Q9UHS4
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UniProt Splice Variant |
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Entrez Gene |
5586
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UniGene |
Hs.703016
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RefSeq |
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HUGO |
HGNC:9406
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OMIM |
602549
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CCDS |
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HPRD |
03972
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IMGT |
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EMBL |
AC119426
AF118089
AK298595
AK300304
AK301066
AL136381
BC125199
CH471097
S75548
U33052
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GenPept |
AAB33346
AAC50208
AAF22033
AAI25200
BAG60783
BAG62057
BAG62673
CAI23271
EAW73161
EAW73164
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