Version 5.4
Homo sapiens Protein: GBP5
Summary
InnateDB Protein IDBP-100182.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GBP5
Protein Name guanylate binding protein 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359488
InnateDB Gene IDBG-100180 (GBP5)
Protein Structure
UniProt Annotation
Function Stimulates the NLRP3 inflammasome assembly upon bacterial challenge. {ECO:0000269PubMed:22461501}.
Subcellular Localization Cytoplasm. Membrane; Lipid-anchor.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0042802 identical protein binding
Biological Process
GO:0006184 GTP catabolic process
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR003191 Guanylate-binding protein, C-terminal
IPR015894 Guanylate-binding protein, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF02841
PF02263
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96PP8
PhosphoSite PhosphoSite-Q96PP8
TrEMBL E7ETN8
UniProt Splice Variant
Entrez Gene 115362
UniGene Hs.602752
RefSeq NP_443174
HUGO HGNC:19895
OMIM 611467
CCDS CCDS722
HPRD 13571
IMGT
EMBL AC099063 AF288815 AF328727 AF430642 AF430643 AK315064 AY358953 BC031639 CH471097
GenPept AAH31639 AAL02055 AAN39035 AAN39036 AAO40731 AAQ89312 BAG37538 EAW73141

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca