Version 5.4
Homo sapiens Protein: LRRC8B
Summary
InnateDB Protein IDBP-100192.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRC8B
Protein Name leucine rich repeat containing 8 family, member B
Synonyms TA-LRRP; TALRRP;
Species Homo sapiens
Ensembl Protein ENSP00000350933
InnateDB Gene IDBG-100188 (LRRC8B)
Protein Structure
UniProt Annotation
Function Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8B constitutes a pore-forming subunit or whether it is closely associated with the pore (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR021040 Leucine-rich repeat-containing protein 8, N-terminal
PFAM PF12534
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P9F7
PhosphoSite PhosphoSite-Q6P9F7
TrEMBL Q537H9
UniProt Splice Variant
Entrez Gene 23507
UniGene Hs.741594
RefSeq
HUGO HGNC:30692
OMIM 612888
CCDS
HPRD 18145
IMGT
EMBL AC099569 AF385436 AY358112 AY640232 BC030607 BC060782 CH471097 D86984
GenPept AAH30607 AAH60782 AAM43837 AAQ88479 AAU14245 BAA13220 EAW73137 EAW73138

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca