Version 5.4
Homo sapiens Protein: LRRC8D
Summary
InnateDB Protein IDBP-100200.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRC8D
Protein Name leucine rich repeat containing 8 family, member D
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000338887
InnateDB Gene IDBG-100198 (LRRC8D)
Protein Structure
UniProt Annotation
Function Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8D constitutes a pore-forming subunit or whether it is closely associated with the pore (By similarity). Mediates the import of the antibiotic blasticidin-S into cell (PubMed:24782309). {ECO:0000250, ECO:0000269PubMed:24782309}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:24782309}; Multi-pass membrane protein {ECO:0000269PubMed:24782309}. Endoplasmic reticulum membrane {ECO:0000269PubMed:24782309}; Multi-pass membrane protein {ECO:0000269PubMed:24782309}. Note=Mainly localizes in the endoplasmic reticulum. {ECO:0000269PubMed:24782309}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR021040 Leucine-rich repeat-containing protein 8, N-terminal
PFAM PF00560
PF13504
PF13855
PF12534
PRINTS
PIRSF
SMART SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7L1W4
PhosphoSite PhosphoSite-Q7L1W4
TrEMBL Q659A9
UniProt Splice Variant
Entrez Gene 55144
UniGene Hs.605166
RefSeq NP_001127951
HUGO HGNC:16992
OMIM 612890
CCDS CCDS726
HPRD 11287
IMGT
EMBL AC099568 AK001332 AL391497 AL831880 AL832952 AY358874 BC024159 CH471097
GenPept AAH24159 AAQ89233 BAA91631 CAH56273 CAH56285 CAH72226 EAW73130 EAW73131 EAW73132

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca