InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TGFBR3

Summary

InnateDB Protein

IDBP-100248.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TGFBR3

Protein Name

transforming growth factor, beta receptor III

Synonyms

betaglycan; BGCAN;

Species

Homo sapiens

Ensembl Protein

ENSP00000212355

InnateDB Gene

IDBG-100244 (TGFBR3)

Protein Structure

UniProt Annotation

Function

Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

Subcellular Localization

Secreted. Secreted, extracellular space. Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005114	type II transforming growth factor beta receptor binding
GO:0005160	transforming growth factor beta receptor binding
GO:0005515	protein binding
GO:0005539	glycosaminoglycan binding
GO:0008201	heparin binding
GO:0015026	coreceptor activity
GO:0017134	fibroblast growth factor binding
GO:0030165	PDZ domain binding
GO:0046332	SMAD binding
GO:0048185	activin binding
GO:0050431	transforming growth factor beta binding
GO:0070123	transforming growth factor beta receptor activity, type III

Biological Process

GO:0001568	blood vessel development
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001824	blastocyst development
GO:0001837	epithelial to mesenchymal transition
GO:0001889	liver development
GO:0003007	heart morphogenesis
GO:0006461	protein complex assembly
GO:0006955	immune response
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007181	transforming growth factor beta receptor complex assembly
GO:0010633	negative regulation of epithelial cell migration
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0016049	cell growth
GO:0016477	cell migration
GO:0030509	BMP signaling pathway
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100	organ regeneration
GO:0032354	response to follicle-stimulating hormone
GO:0034695	response to prostaglandin E
GO:0034699	response to luteinizing hormone stimulus
GO:0035556	intracellular signal transduction
GO:0043393	regulation of protein binding
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051271	negative regulation of cellular component movement
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060021	palate development
GO:0060038	cardiac muscle cell proliferation
GO:0060216	definitive hemopoiesis
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060318	definitive erythrocyte differentiation
GO:0060347	heart trabecula formation
GO:0060389	pathway-restricted SMAD protein phosphorylation

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0034673	inhibin-betaglycan-ActRII complex
GO:0070062	extracellular vesicular exosome