InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GLMN

Summary

InnateDB Protein

IDBP-100274.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLMN

Protein Name

glomulin, FKBP associated protein

Synonyms

FAP; FAP48; FAP68; FKBPAP; GLML; GVM; VMGLOM;

Species

Homo sapiens

Ensembl Protein

ENSP00000359385

InnateDB Gene

IDBG-100272 (GLMN)

Protein Structure

UniProt Annotation

Function

Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cell proliferation and increase IL2 production. {ECO:0000269PubMed:11571281, ECO:0000269PubMed:12604780}.

Subcellular Localization

Disease Associations

Glomuvenous malformations (GVMs) [MIM:138000]: Characterized by the presence of smooth-muscle-like glomus cells in the media surrounding distended vascular lumens. {ECO:0000269PubMed:11845407}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	27 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005171	hepatocyte growth factor receptor binding
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0055105	ubiquitin-protein transferase inhibitor activity

Biological Process

GO:0001570	vasculogenesis
GO:0001843	neural tube closure
GO:0031397	negative regulation of protein ubiquitination
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0040029	regulation of gene expression, epigenetic
GO:0042130	negative regulation of T cell proliferation
GO:0042327	positive regulation of phosphorylation
GO:0042692	muscle cell differentiation
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0050715	positive regulation of cytokine secretion
GO:0072359	circulatory system development

Cellular Component

GO:0005622	intracellular
GO:0031461	cullin-RING ubiquitin ligase complex
GO:0031462	Cul2-RING ubiquitin ligase complex
GO:0031463	Cul3-RING ubiquitin ligase complex
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex