InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPL5

Summary

InnateDB Protein

IDBP-100294.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL5

Protein Name

ribosomal protein L5

Synonyms

DBA6; L5; PPP1R135;

Species

Homo sapiens

Ensembl Protein

ENSP00000359345

InnateDB Gene

IDBG-100292 (RPL5)

Protein Structure

UniProt Annotation

Function

Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA. {ECO:0000269PubMed:19061985}.

Subcellular Localization

Cytoplasm {ECO:0000269Ref.7}. Nucleus, nucleolus {ECO:0000269Ref.7}.

Disease Associations

Diamond-Blackfan anemia 6 (DBA6) [MIM:612561]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269PubMed:19061985, ECO:0000269PubMed:19191325}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 181 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	181 [view]
Protein-Protein	178 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008097	5S rRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0042273	ribosomal large subunit biogenesis
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0030529	ribonucleoprotein complex
GO:0070062	extracellular vesicular exosome