Version 5.4
Homo sapiens Protein: TMED5
Summary
InnateDB Protein IDBP-100315.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMED5
Protein Name transmembrane emp24 protein transport domain containing 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359305
InnateDB Gene IDBG-100311 (TMED5)
Protein Structure
UniProt Annotation
Function Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle- mediated retrograde transport. {ECO:0000269PubMed:19948005}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:19948005}; Single-pass type I membrane protein {ECO:0000269PubMed:19948005}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269PubMed:19948005}; Single-pass type I membrane protein {ECO:0000269PubMed:19948005}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269PubMed:19948005}; Single-pass type I membrane protein {ECO:0000269PubMed:19948005}. Note=Probably cycles between compartments of the early secretatory pathway.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0015031 protein transport
GO:0090161 Golgi ribbon formation
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005801 cis-Golgi network
GO:0016021 integral component of membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0070971 endoplasmic reticulum exit site
Protein Structure and Domains
PDB ID
InterPro IPR009038 GOLD
PFAM PF01105
PF13897
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y3A6
PhosphoSite PhosphoSite-Q9Y3A6
TrEMBL
UniProt Splice Variant
Entrez Gene 50999
UniGene Hs.714024
RefSeq NP_057124
HUGO HGNC:24251
OMIM
CCDS CCDS743
HPRD 13028
IMGT
EMBL AC126124 AF151858 AK312787 AL117354 AY359039 BC016365 BC016556 BC070051 BX379269 CH471097
GenPept AAD34095 AAH16365 AAH16556 AAH70051 AAQ89398 BAG35650 CAI23500 CAI23501 EAW73081 EAW73082

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca