InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCD3

Summary

InnateDB Protein

IDBP-100377.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCD3

Protein Name

ATP-binding cassette, sub-family D (ALD), member 3

Synonyms

ABC43; PMP70; PXMP1; ZWS2;

Species

Homo sapiens

Ensembl Protein

ENSP00000359233

InnateDB Gene

IDBG-100373 (ABCD3)

Protein Structure

UniProt Annotation

Function

Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity. {ECO:0000269PubMed:11248239}.

Subcellular Localization

Peroxisome membrane {ECO:0000269PubMed:10704444}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00441, ECO:0000269PubMed:10704444}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0042803	protein homodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006810	transport
GO:0007031	peroxisome organization
GO:0042760	very long-chain fatty acid catabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005782	peroxisomal matrix
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR005283 Peroxysomal long chain fatty acyl transporter
IPR010509 Peroxisomal fatty acyl CoA transporter, transmembrane domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00005
PF06472

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P28288