InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HS3ST1

Summary

InnateDB Protein

IDBP-10052.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HS3ST1

Protein Name

heparan sulfate (glucosamine) 3-O-sulfotransferase 1

Synonyms

3OST; 3OST1;

Species

Homo sapiens

Ensembl Protein

ENSP00000002596

InnateDB Gene

IDBG-10050 (HS3ST1)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. {ECO:0000269PubMed:9346953}.

Subcellular Localization

Golgi apparatus lumen {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in the brain and kidney and weakly expressed in the heart, lung and placenta. {ECO:0000269PubMed:9988767}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0044281	small molecule metabolic process