Version 5.4
Homo sapiens Protein: DPH5
Summary
InnateDB Protein IDBP-100550.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPH5
Protein Name DPH5 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359127
InnateDB Gene IDBG-100546 (DPH5)
Protein Structure
UniProt Annotation
Function S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EEF2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. {ECO:0000269PubMed:23486472}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004164 diphthine synthase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0008152 metabolic process
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine
GO:0032259 methylation
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID
InterPro IPR000878 Tetrapyrrole methylase
IPR004551 Diphthine synthase
PFAM PF00590
PRINTS
PIRSF PIRSF036432
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H2P9
PhosphoSite PhosphoSite-Q9H2P9
TrEMBL Q96DC6
UniProt Splice Variant
Entrez Gene 51611
UniGene Hs.440776
RefSeq NP_057042
HUGO HGNC:24270
OMIM 611075
CCDS CCDS41358
HPRD 13037
IMGT
EMBL AC093157 AF132964 AF157319 AF161492 AF248965 AK125485 AK289351 BC009620 BC053857 CH471097
GenPept AAD27739 AAF29107 AAF67485 AAG44563 AAH09620 AAH53857 BAF82040 BAG54203 EAW72933 EAW72934 EAW72936 EAW72937 EAW72938 EAW72940 EAW72941

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca