InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: S1PR1

Summary

InnateDB Protein

IDBP-100564.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S1PR1

Protein Name

sphingosine-1-phosphate receptor 1

Synonyms

CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1; S1P1;

Species

Homo sapiens

Ensembl Protein

ENSP00000305416

InnateDB Gene

IDBG-100562 (S1PR1)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3- phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. {ECO:0000250, ECO:0000269PubMed:10982820, ECO:0000269PubMed:11230698, ECO:0000269PubMed:11583630, ECO:0000269PubMed:11604399, ECO:0000269PubMed:19286607, ECO:0000269PubMed:22344443, ECO:0000269PubMed:8626678, ECO:0000269PubMed:9488656}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl- 2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.

Disease Associations

Tissue Specificity

Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0004930	G-protein coupled receptor activity
GO:0038036	sphingosine-1-phosphate receptor activity
GO:0046625	sphingolipid binding

Biological Process

GO:0001525	angiogenesis
GO:0001955	blood vessel maturation
GO:0003245	cardiac muscle tissue growth involved in heart morphogenesis
GO:0003376	sphingosine-1-phosphate signaling pathway
GO:0006935	chemotaxis
GO:0007155	cell adhesion
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007420	brain development
GO:0008284	positive regulation of cell proliferation
GO:0016477	cell migration
GO:0019226	transmission of nerve impulse
GO:0030032	lamellipodium assembly
GO:0030155	regulation of cell adhesion
GO:0030182	neuron differentiation
GO:0030335	positive regulation of cell migration
GO:0030500	regulation of bone mineralization
GO:0031532	actin cytoskeleton reorganization
GO:0032320	positive regulation of Ras GTPase activity
GO:0045124	regulation of bone resorption
GO:0045446	endothelial cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050927	positive regulation of positive chemotaxis
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051497	negative regulation of stress fiber assembly
GO:0061384	heart trabecula morphogenesis
GO:0072678	T cell migration

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0031226	intrinsic component of plasma membrane
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000987 EDG-1 sphingosine 1-phosphate receptor
IPR001671 Melanocortin/ACTH receptor
IPR004061 Sphingosine 1-phosphate receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00642
PR00534
PR01523

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21453