InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZFYVE26

Summary

InnateDB Protein

IDBP-10061.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFYVE26

Protein Name

zinc finger, FYVE domain containing 26

Synonyms

FYVE-CENT; SPG15;

Species

Homo sapiens

Ensembl Protein

ENSP00000251119

InnateDB Gene

IDBG-10059 (ZFYVE26)

Protein Structure

UniProt Annotation

Function

Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269PubMed:20208530}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:20208530}. Midbody {ECO:0000269PubMed:20208530}. Note=Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A.

Disease Associations

Spastic paraplegia 15, autosomal recessive (SPG15) [MIM:270700]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG15 is a complex form associated with additional neurological symptoms such as cognitive deterioration or mental retardation, axonal neuropathy, mild cerebellar signs, and, less frequently, a central hearing deficit, decreased visual acuity, or retinal degeneration. {ECO:0000269PubMed:18394578, ECO:0000269PubMed:19084844, ECO:0000269PubMed:19805727}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. {ECO:0000269PubMed:18394578}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0046872	metal ion binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0000910	cytokinesis
GO:0008219	cell death

Cellular Component

GO:0005765	lysosomal membrane
GO:0005813	centrosome
GO:0030496	midbody

Protein Structure and Domains

PDB ID

InterPro

IPR000306 FYVE zinc finger
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related

PFAM

PF01363

PRINTS

PIRSF

SMART

SM00064

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q68DK2

PhosphoSite

PhosphoSite-Q68DK2

TrEMBL

UniProt Splice Variant

Entrez Gene

23503

UniGene

Hs.98041

RefSeq

NP_056161

HUGO

HGNC:20761

OMIM

612012

CCDS

CCDS9788

HPRD

15734

IMGT

EMBL

AB002319 AB425197 AK128496 AK304428 AL049779 AL121595 BC033235 BX537886 BX538025 BX648683 CH471061 CR749276 CR749365

GenPept

AAH33235 BAA20779 BAC87467 BAG11658 BAG65255 CAD97882 CAD97971 CAH10379 CAH18131 CAH18218 EAW80954