Version 5.4
Homo sapiens Protein: NTNG1
Summary
InnateDB Protein IDBP-100632.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NTNG1
Protein Name netrin G1
Synonyms Lmnt1;
Species Homo sapiens
Ensembl Protein ENSP00000359085
InnateDB Gene IDBG-100618 (NTNG1)
Protein Structure
UniProt Annotation
Function Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. {ECO:0000269PubMed:21946559}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:21946559}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:21946559}; Extracellular side {ECO:0000269PubMed:21946559}.
Disease Associations
Tissue Specificity Highly expressed in the thalamus, with very low expression, if any, in other tissues. {ECO:0000269PubMed:14595443, ECO:0000269PubMed:15901489}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007409 axonogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0046658 anchored component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000742 Epidermal growth factor-like domain
IPR002049 EGF-like, laminin
IPR008211 Laminin, N-terminal
PFAM PF00008
PF00053
PF00055
PRINTS
PIRSF
SMART SM00181
SM00180
SM00136
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2I2
PhosphoSite PhosphoSite-Q9Y2I2
TrEMBL Q5IEC8
UniProt Splice Variant
Entrez Gene 22854
UniGene Hs.732535
RefSeq
HUGO HGNC:23319
OMIM 608818
CCDS CCDS44180
HPRD 16389
IMGT
EMBL AB023193 AC114491 AL513187 AL590427 AY358365 AY764260 BC030220 BX538348
GenPept AAH30220 AAQ88731 AAW47407 BAA76820 CAD98143 CAH73380 CAH73381 CAH73382 CAH73383 CAH73384 CAH73385 CAH73828 CAH73829 CAH73830 CAH73831 CAH73832 CAH73833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca