InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STXBP3

Summary

InnateDB Protein

IDBP-100706.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STXBP3

Protein Name

syntaxin binding protein 3

Synonyms

MUNC18-3; MUNC18C; PSP; UNC-18C;

Species

Homo sapiens

Ensembl Protein

ENSP00000359025

InnateDB Gene

IDBG-100704 (STXBP3)

Protein Structure

UniProt Annotation

Function

Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:10194441}. Cell membrane {ECO:0000269PubMed:10194441}. Note=In platelets, predominantly cytosolic. Low amounts membrane-associated.

Disease Associations

Tissue Specificity

Megakaryocytes and platelets.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017075	syntaxin-1 binding
GO:0019905	syntaxin binding

Biological Process

GO:0006904	vesicle docking involved in exocytosis
GO:0007596	blood coagulation
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0030168	platelet activation
GO:0043312	neutrophil degranulation
GO:0045955	negative regulation of calcium ion-dependent exocytosis
GO:0051291	protein heterooligomerization
GO:0061024	membrane organization
GO:0070527	platelet aggregation

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0031091	platelet alpha granule
GO:0042581	specific granule
GO:0070062	extracellular vesicular exosome
GO:0070820	tertiary granule