InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSTM4

Summary

InnateDB Protein

IDBP-100870.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTM4

Protein Name

glutathione S-transferase mu 4

Synonyms

GSTM4-4; GTM4;

Species

Homo sapiens

Ensembl Protein

ENSP00000358851

InnateDB Gene

IDBG-100866 (GSTM4)

Protein Structure

UniProt Annotation

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1- chloro-2,4-dinitrobenzene.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in a wide variety of tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity
GO:0043295	glutathione binding

Biological Process

GO:0006749	glutathione metabolic process
GO:0006805	xenobiotic metabolic process
GO:0042178	xenobiotic catabolic process
GO:0044281	small molecule metabolic process
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR003081 Glutathione S-transferase, Mu class
IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM