Version 5.4
Homo sapiens Protein: PROK1
Summary
InnateDB Protein IDBP-100986.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PROK1
Protein Name prokineticin 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000271331
InnateDB Gene IDBG-100984 (PROK1)
Protein Structure
UniProt Annotation
Function Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. {ECO:0000269PubMed:11259612, ECO:0000269PubMed:11528470, ECO:0000269PubMed:15292351, ECO:0000269PubMed:17289879, ECO:0000269PubMed:18339712}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta. {ECO:0000269PubMed:11528470, ECO:0000269PubMed:15292351, ECO:0000269PubMed:18339712}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008083 growth factor activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0008284 positive regulation of cell proliferation
GO:0045765 regulation of angiogenesis
GO:0051781 positive regulation of cell division
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR023569 Prokineticin domain
PFAM PF06607
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P58294
PhosphoSite PhosphoSite-P58294
TrEMBL A0A024R0B1
UniProt Splice Variant
Entrez Gene 84432
UniGene Hs.614442
RefSeq NP_115790
HUGO HGNC:18454
OMIM 606233
CCDS CCDS825
HPRD 06946
IMGT
EMBL AF333024 AL358215 AL390797 AY029225 AY358683 BC025399 CH471122
GenPept AAH25399 AAK33111 AAK49918 AAQ89046 CAH71489 CAH74102 EAW56449 EAW56450

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca