InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD53

Summary

InnateDB Protein

IDBP-101006.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD53

Protein Name

CD53 molecule

Synonyms

MOX44; TSPAN25;

Species

Homo sapiens

Ensembl Protein

ENSP00000271324

InnateDB Gene

IDBG-101004 (CD53)

Protein Structure

UniProt Annotation

Function

Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}. Cell junction {ECO:0000250}. Membrane; Multi-pass membrane protein. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes. {ECO:0000250}.

Disease Associations

Tissue Specificity

B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0045087	innate immune response (InnateDB)
GO:1901741	positive regulation of myoblast fusion

Cellular Component

GO:0001772	immunological synapse
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome