InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WDR77

Summary

InnateDB Protein

IDBP-101063.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WDR77

Protein Name

WD repeat domain 77

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000235090

InnateDB Gene

IDBG-101061 (WDR77)

Protein Structure

UniProt Annotation

Function

Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. {ECO:0000269PubMed:11756452, ECO:0000269PubMed:23071334}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors.

Disease Associations

Tissue Specificity

Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors. {ECO:0000269PubMed:12972618, ECO:0000269PubMed:17437848}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	124 [view]
Protein-Protein	123 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity

Biological Process

GO:0000387	spliceosomal snRNP assembly
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0034660	ncRNA metabolic process
GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development