InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MOV10

Summary

InnateDB Protein

IDBP-101157.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MOV10

Protein Name

Mov10, Moloney leukemia virus 10, homolog (mouse)

Synonyms

fSAP113; gb110;

Species

Homo sapiens

Ensembl Protein

ENSP00000358659

InnateDB Gene

IDBG-101151 (MOV10)

Protein Structure

UniProt Annotation

Function

Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA- mediated cleavage of complementary mRNAs by RISC. Also required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269PubMed:16289642, ECO:0000269PubMed:17507929, ECO:0000269PubMed:18552826, ECO:0000269PubMed:22791714}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000269PubMed:16289642}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	71 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0035279	mRNA cleavage involved in gene silencing by miRNA
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling