InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LRIG2

Summary

InnateDB Protein

IDBP-101197.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRIG2

Protein Name

leucine-rich repeats and immunoglobulin-like domains 2

Synonyms

LIG-2; LIG2; UFS2;

Species

Homo sapiens

Ensembl Protein

ENSP00000355396

InnateDB Gene

IDBG-101195 (LRIG2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15145052}; Single-pass type I membrane protein {ECO:0000269PubMed:15145052}. Cytoplasm {ECO:0000269PubMed:15145052}.

Disease Associations

Urofacial syndrome 2 (UFS2) [MIM:615112]: A rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure. {ECO:0000269PubMed:23313374}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Detected in all tissues analyzed. {ECO:0000269PubMed:15145052}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007605	sensory perception of sound
GO:0010640	regulation of platelet-derived growth factor receptor signaling pathway
GO:0060384	innervation

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF01463
PF00560
PF13504
PF13855
PF07679
PF00047

PRINTS

PIRSF

SMART

SM00082
SM00369
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O94898