InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AP4B1

Summary

InnateDB Protein

IDBP-101247.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP4B1

Protein Name

adaptor-related protein complex 4, beta 1 subunit

Synonyms

BETA-4; CPSQ5; SPG47;

Species

Homo sapiens

Ensembl Protein

ENSP00000256658

InnateDB Gene

IDBG-101239 (AP4B1)

Protein Structure

UniProt Annotation

Function

Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.

Subcellular Localization

Golgi apparatus, trans-Golgi network {ECO:0000269PubMed:22472443}. Membrane, coated pit {ECO:0000250}. Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells.

Disease Associations

Cerebral palsy, spastic quadriplegic 5 (CPSQ5) [MIM:614066]: A neurodevelopmental disorder characterized by neonatal hypotonia that progresses to hypertonia and spasticity, and severe mental retardation with poor or absent speech development. {ECO:0000269PubMed:21620353}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	9 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005488	binding
GO:0008565	protein transporter activity

Biological Process

GO:0006886	intracellular protein transport
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005905	coated pit
GO:0030117	membrane coat
GO:0030131	clathrin adaptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
IPR015151 Beta-adaptin appendage, C-terminal subdomain
IPR016024 Armadillo-type fold
IPR016342 AP-1, 2,4 complex subunit beta

PFAM

PF01602
PF09066

PRINTS

PIRSF

PIRSF002291

SMART

SM01020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt