Homo sapiens Protein: TRIM33
Summary
InnateDB Protein IDBP-101288.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM33
Protein Name tripartite motif containing 33
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000351250
InnateDB Gene IDBG-101286 (TRIM33)
Protein Structure
UniProt Annotation
Function Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade). {ECO:0000250, ECO:0000269PubMed:10022127, ECO:0000269PubMed:15820681, ECO:0000269PubMed:16751102, ECO:0000269PubMed:19135894}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15820681, ECO:0000269PubMed:16751102, ECO:0000269PubMed:19135894}. Note=In discrete nuclear dots resembling nuclear bodies. {ECO:0000250}.
Disease Associations Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving TRIM33 is found in thyroid papillary carcinomas. Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene.
Tissue Specificity Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoietic progenitors.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 66 [view]
Protein-Protein 63 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0070410 co-SMAD binding
GO:0070412 R-SMAD binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0010467 gene expression
GO:0016567 protein ubiquitination
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR000315 Zinc finger, B-box
IPR001487 Bromodomain
IPR001841 Zinc finger, RING-type
IPR001965 Zinc finger, PHD-type
IPR003649 B-box, C-terminal
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger
PFAM PF00643
PF00439
PF13639
PF14634
PF00628
PRINTS PR00503
PIRSF
SMART SM00336
SM00297
SM00184
SM00249
SM00502
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UPN9
PhosphoSite PhosphoSite-Q9UPN9
TrEMBL
UniProt Splice Variant
Entrez Gene 51592
UniGene Hs.734228
RefSeq NP_056990
HUGO HGNC:16290
OMIM 605769
CCDS CCDS872
HPRD 10423
IMGT
EMBL AB029036 AF119043 AF220136 AF220137 AJ132948 AL035410 AL390241
GenPept AAD17259 AAG53509 AAG53510 BAA83065 CAB55313 CAI13548 CAI13550 CAI13551 CAI21895 CAI21896 CAI21897