Version 5.4
Homo sapiens Protein: BCAS2
Summary
InnateDB Protein IDBP-101293.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCAS2
Protein Name breast carcinoma amplified sequence 2
Synonyms DAM1; Snt309; SPF27;
Species Homo sapiens
Ensembl Protein ENSP00000358554
InnateDB Gene IDBG-101291 (BCAS2)
Protein Structure
UniProt Annotation
Function Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:12169396, ECO:0000269PubMed:12429849, ECO:0000269PubMed:20176811}.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:10403562}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
Experimentally validated
Total 69 [view]
Protein-Protein 68 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR008409 Pre-mRNA-splicing factor SPF27
PFAM PF05700
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75934
PhosphoSite PhosphoSite-O75934
TrEMBL B2R7W3
UniProt Splice Variant
Entrez Gene 10286
UniGene Hs.705619
RefSeq NP_005863
HUGO HGNC:975
OMIM 605783
CCDS CCDS874
HPRD 05777
IMGT
EMBL AB020623 AB451245 AB451369 AF081788 AK313141 AL390241 BC005285 BC012623 BC022880 BT019390 CH471122 CR542037
GenPept AAC64059 AAH05285 AAH12623 AAH22880 AAV38197 BAA34863 BAG35960 BAG70059 BAG70183 CAG46834 CAI13553 EAW56602

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca