Version 5.4
Homo sapiens Protein: MPPE1
Summary
InnateDB Protein IDBP-1013.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPPE1
Protein Name metallophosphoesterase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000311200
InnateDB Gene IDBG-1009 (MPPE1)
Protein Structure
UniProt Annotation
Function Metallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins. {ECO:0000269PubMed:19837036}.
Subcellular Localization Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269PubMed:19837036}; Multi-pass membrane protein {ECO:0000269PubMed:19837036}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269PubMed:19837036}; Multi- pass membrane protein {ECO:0000269PubMed:19837036}. Note=Also localizes to endoplasmic reticulum exit site.
Disease Associations
Tissue Specificity Expressed in brain. {ECO:0000269PubMed:11978971}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008081 phosphoric diester hydrolase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0034235 GPI anchor binding
Biological Process
GO:0006506 GPI anchor biosynthetic process
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0008152 metabolic process
Cellular Component
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005801 cis-Golgi network
GO:0016021 integral component of membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0070971 endoplasmic reticulum exit site
Protein Structure and Domains
PDB ID
InterPro IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like
PFAM PF00149
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q53F39
PhosphoSite PhosphoSite-Q53F39
TrEMBL K7ESB8
UniProt Splice Variant
Entrez Gene 65258
UniGene Hs.712666
RefSeq NP_001229833
HUGO HGNC:15988
OMIM 611900
CCDS CCDS56054
HPRD 14734
IMGT
EMBL AF289560 AF363482 AF363483 AF363484 AK021647 AK023052 AK223450 AP001269 BC002877 BC073994 CH471113 EF444996
GenPept AAH02877 AAH73994 AAL55744 AAM00277 AAM00278 AAM00279 ACA06017 ACA06018 ACA06019 BAB13863 BAB14378 BAD97170 EAX01562 EAX01564 EAX01565 EAX01567 EAX01568 EAX01569 EAX01571

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca