InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC22A15

Summary

InnateDB Protein

IDBP-101373.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC22A15

Protein Name

solute carrier family 22, member 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000358514

InnateDB Gene

IDBG-101369 (SLC22A15)

Protein Structure

UniProt Annotation

Function

Probably transports organic cations (By similarity). Appears not to be the agmatine transporter. {ECO:0000250, ECO:0000269PubMed:15028572}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed at highest levels in kidney and brain. Expressed at high levels in skeletal muscle, heart, liver, placenta and white blood cells. Expressed at moderate levels in lung and spleen. Expressed at low levels in thymus, small intestine and colon. Expressed in several intestinal tumor cell lines. {ECO:0000269PubMed:12372408, ECO:0000269PubMed:15028572}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006811	ion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IZD6

PhosphoSite