InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD2

Summary

InnateDB Protein

IDBP-101419.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD2

Protein Name

CD2 molecule

Synonyms

LFA-2; SRBC; T11;

Species

Homo sapiens

Ensembl Protein

ENSP00000358490

InnateDB Gene

IDBG-101417 (CD2)

Protein Structure

UniProt Annotation

Function

CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001766	membrane raft polarization
GO:0006915	apoptotic process
GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007596	blood coagulation
GO:0016337	single organismal cell-cell adhesion
GO:0030101	natural killer cell activation
GO:0030887	positive regulation of myeloid dendritic cell activation
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034113	heterotypic cell-cell adhesion
GO:0042110	T cell activation
GO:0045580	regulation of T cell differentiation
GO:0050900	leukocyte migration
GO:1902715	positive regulation of interferon-gamma secretion
GO:2000484	positive regulation of interleukin-8 secretion

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0009897	external side of plasma membrane
GO:0009898	cytoplasmic side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0046658	anchored component of plasma membrane