InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD101

Summary

InnateDB Protein

IDBP-101427.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD101

Protein Name

CD101 molecule

Synonyms

EWI-101; IGSF2; V7;

Species

Homo sapiens

Ensembl Protein

ENSP00000358482

InnateDB Gene

IDBG-101425 (CD101)

Protein Structure

UniProt Annotation

Function

Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3- induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. {ECO:0000269PubMed:11093127, ECO:0000269PubMed:15737213, ECO:0000269PubMed:7722299, ECO:0000269PubMed:9233604, ECO:0000269PubMed:9389317, ECO:0000269PubMed:9647226}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients. {ECO:0000269PubMed:10692025, ECO:0000269PubMed:15737213, ECO:0000269PubMed:7722299, ECO:0000269PubMed:7722300, ECO:0000269PubMed:9389317}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0008152	metabolic process

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain

PFAM

PF07679
PF07686

PRINTS

PIRSF

SMART

SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q93033