Version 5.4
Homo sapiens Protein: REG4
Summary
InnateDB Protein IDBP-101532.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol REG4
Protein Name regenerating islet-derived family, member 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000346158
InnateDB Gene IDBG-101530 (REG4)
Protein Structure
UniProt Annotation
Function Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. {ECO:0000269PubMed:12819006, ECO:0000269PubMed:20692269}.
Subcellular Localization Secreted {ECO:0000269PubMed:12819006}.
Disease Associations
Tissue Specificity Highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. Weakly expressed in normal colon and stomach. Strongly expressed in most colorectal tumors than in normal colon. Preferentially expressed in mucinous tumors and in some cases neuro-endocrine tumors. Expressed in mucus-secreting cells and enterocyte-like cells. In small intestine expressed at the basal perinuclear zone of goblet cells. {ECO:0000269PubMed:11311942, ECO:0000269PubMed:12455032, ECO:0000269PubMed:12819006}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008201 heparin binding
GO:2001065 mannan binding
Biological Process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BYZ8
PhosphoSite PhosphoSite-Q9BYZ8
TrEMBL A0A024R0M1
UniProt Splice Variant
Entrez Gene 83998
UniGene Hs.660883
RefSeq NP_001152824
HUGO HGNC:22977
OMIM 609846
CCDS CCDS906
HPRD 17964
IMGT
EMBL AF254415 AF345934 AL359752 AY007243 AY126670 AY126671 AY126672 BC017089 CH471122
GenPept AAG02562 AAH17089 AAK48435 AAK59869 AAM95598 AAM95599 AAM95600 CAI18972 CAI18973 EAW56713 EAW56714

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca