Homo sapiens Protein: NOTCH2NL
Summary
InnateDB Protein IDBP-101674.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOTCH2NL
Protein Name notch 2 N-terminal like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000354929
InnateDB Gene IDBG-244347 (NOTCH2NL)
Protein Structure
UniProt Annotation
Function May function in the Notch signaling pathway and regulate neutrophil differentiation. {ECO:0000269PubMed:14673143}.
Subcellular Localization Secreted {ECO:0000269PubMed:14673143}. Cytoplasm {ECO:0000269PubMed:14673143}.
Disease Associations
Tissue Specificity Widely expressed with higher levels in leukocytes and lymph nodes. {ECO:0000269PubMed:14673143}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organismal development
GO:0030154 cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR013111 EGF-like domain, extracellular
PFAM PF00008
PF07645
PF07974
PRINTS
PIRSF
SMART SM00181
SM00179
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z3S9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 388677
UniGene Hs.619910
RefSeq NP_982283
HUGO HGNC:31862
OMIM
CCDS CCDS72880
HPRD 14833
IMGT
EMBL AK075065 AL592307 BC010154 BC019835 BC065219 BC084572 BC090943 BX537434
GenPept AAH10154 AAH19835 AAH65219 AAH84572 AAH90943 BAC11381 CAD97676 CAH73993 CAH73994