Version 5.4
Homo sapiens Protein: HIST2H3C
Summary
InnateDB Protein IDBP-101993.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST2H3C
Protein Name histone cluster 2, H3c
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000358154
InnateDB Gene IDBG-101991 (HIST2H3C)
Protein Structure
UniProt Annotation
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization Nucleus. Chromosome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 109 experimentally validated interaction(s) in this database.
Experimentally validated
Total 109 [view]
Protein-Protein 107 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0007596 blood coagulation
Cellular Component
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000164 Histone H3/CENP-A
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00125
PRINTS PR00622
PIRSF
SMART SM00428
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q71DI3
PhosphoSite PhosphoSite-Q71DI3
TrEMBL V9H1G0
UniProt Splice Variant
Entrez Gene 653604
UniGene Hs.706618
RefSeq NP_066403
HUGO HGNC:20503
OMIM 142780
CCDS CCDS30848
HPRD 11822
IMGT
EMBL AF531305 AF531307 AL591493 AY648851 BC074969 BC130635 BC130637 V00521
GenPept AAH74969 AAI30636 AAI30638 AAN39283 AAT68254 CAA23780 CAI12559 CAI12561 CAI12566

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca