InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VPS45

Summary

InnateDB Protein

IDBP-102047.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS45

Protein Name

vacuolar protein sorting 45 homolog (S. cerevisiae)

Synonyms

H1; H1VPS45; SCN5; VPS45A; VPS45B; VPS54A; VSP45; VSP45A;

Species

Homo sapiens

Ensembl Protein

ENSP00000358126

InnateDB Gene

IDBG-102045 (VPS45)

Protein Structure

UniProt Annotation

Function

May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with Golgi/endosomal vesicles and the trans-Golgi network. {ECO:0000250}.

Disease Associations

Neutropenia, severe congenital 5, autosomal recessive (SCN5) [MIM:615285]: An autosomal recessive primary immunodeficiency disorder characterized primarily by neutropenia and neutrophil dysfunction, a lack of response to G-CSF, life- threatening infections, bone marrow fibrosis, and renal extramedullary hematopoiesis. {ECO:0000269PubMed:23738510}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006904	vesicle docking involved in exocytosis
GO:0007596	blood coagulation
GO:0016192	vesicle-mediated transport
GO:0045087	innate immune response (InnateDB)