InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLEKHO1

Summary

InnateDB Protein

IDBP-102056.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLEKHO1

Protein Name

pleckstrin homology domain containing, family O member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000358120

InnateDB Gene

IDBG-102050 (PLEKHO1)

Protein Structure

UniProt Annotation

Function

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT- mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. {ECO:0000269PubMed:14729969, ECO:0000269PubMed:15706351, ECO:0000269PubMed:15831458, ECO:0000269PubMed:16325375, ECO:0000269PubMed:16987810, ECO:0000269PubMed:17197158, ECO:0000269PubMed:17942896}.

Subcellular Localization

Cell membrane. Nucleus. Cytoplasm. Note=Predominantly localized to the plasma membrane. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells.

Disease Associations

Tissue Specificity

Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cell lines such as MOLT-4, HEK293 and Jurkat. {ECO:0000269PubMed:17197158}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.