Version 5.4
Homo sapiens Protein: HORMAD1
Summary
InnateDB Protein IDBP-102180.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HORMAD1
Protein Name HORMA domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355167
InnateDB Gene IDBG-102176 (HORMAD1)
Protein Structure
UniProt Annotation
Function Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Testis-specific. Over-expressed in carcinomas. {ECO:0000269PubMed:15999985}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001824 blastocyst development
GO:0007126 meiotic nuclear division
GO:0007130 synaptonemal complex assembly
GO:0007283 spermatogenesis
GO:0042138 meiotic DNA double-strand break formation
GO:0048477 oogenesis
GO:0051177 meiotic sister chromatid cohesion
GO:0051598 meiotic recombination checkpoint
GO:0060629 regulation of homologous chromosome segregation
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005694 chromosome
Protein Structure and Domains
PDB ID
InterPro IPR003511 DNA-binding HORMA
PFAM PF02301
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86X24
PhosphoSite PhosphoSite-Q86X24
TrEMBL
UniProt Splice Variant
Entrez Gene 84072
UniGene Hs.298312
RefSeq NP_115508
HUGO HGNC:25245
OMIM 609824
CCDS CCDS967
HPRD 11396
IMGT
EMBL AK097390 AL136755 AL356292 AY626344 BC033014 BC047406 CH471121 CR533505
GenPept AAH33014 AAH47406 AAT45740 BAG53463 CAB66689 CAG38536 CAI13652 CAI13653 CAI13654 CAI13655 CAI13656 EAW53523

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca